A reagent for synthesis of trifluoromethyl heterocycles.1 Used in synthesis of CF3-substituted triarylethenes by stereoselective threefold cross-coupling reactions with aryl boronic acids,2 formation of trifluoropyruvaldehyde hydrate as a useful intermediate for the synthesis of a fused pyrazine derivative,3 and intramolecular Diels-Alder cycloaddition to S-methylthiosemicarbazide for preparing 3-methylthio-6-trifluoromethyl-1,2,4-triazine.4 Also employed in preparation of imidazolylpyrazolylvinylpyridines as inhibitors of ATP-protein kinase interactions,5 preparation of pyridazinone derivatives as herbicide intermediates,6 and synthesis of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.7
References
1. Indian J. Chem. Sect. B 1988, 27B, 1051.
2. Angew. Chem. Int. Ed. 2007, 46, 8659.
3. J. Org. Chem. 1993, 58, 4033.
4. Arch. Pharm. 1992, 325, 349.
5. WO 2008048503 A2 20080424, 2008.
6. EP 1371638 A1 20031217, 2003.
7. Cancer Ther. 2004, 3, 1427.