Reagent used in organic synthesis. A powerful building block for enantiopure chirons in trifluoromethyl-β-amino acid series.1 Has applications in alkylation,2 equilibrium-dependent hydration,3 microbial synthesis of ethyl (R)-4,4,4-trifluoro-3-hydroxybutanoate by asymmetric reduction,4 synthesis of 2-trifluoromethyl-4- and 4-trifluoromethyl-2-quinolinones by reactions between ethyl 4,4,4-trifluoroacetoacetate and various anilines,5 and Platinum-catalyzed enantioselective hydrogenation.6
1. J. Fluorine Chem. 2007, 128, 889.
2. J. Chem. Soc., Chem. Commun. 1989, 83.
3. Enzyme Microb. Technol. 2003, 32, 491.
4. Biotechnol J. 2007, 2, 260.
5. Synthesis 2003, 2005.
6. Catal. Lett. 2002, 78, 267.