Coupling reagent for peptide synthesis. A good alternative to HBTU and TBTU because the presence of the Cl-HOBt makes it more reactive and it shows improved performance in difficult or hindered couplings and cyclizations when compared to HBTU.2,3,4 An excellent alternative to the most classic methods for the large scale manufacturing of peptide and proteins.5
1. Chim. Oggi 2002, 20, 37.
2. Lett. Pept. Sci. 2002, 9, 119.
3. Synthesis 2005, 16, 2687.
4. Chem. Eur. J. 2009, 15, 9394.
5. Chim. Oggi 2003, 21, 6.