A coupling reagent in peptide synthesis.1 A useful alternative to HATU/HBTU/HCTU under aqueous reaction conditions. 2,3 Reagent for the clean in-situ formation of N-succinimidyl active esters.4,5 Also can be used in the development of piezoelectric immunosensors as an activator.6 Simultaneous use of HOSu and CuCl2 with TSTU, has been found to eliminate the racemization of the carboxy-terminal N-methylamino acid residue during segment condensation.7
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6. Sens. Actuators, B 2003, B91, 333.
7. Pep. Sci. 1999, 36, 107