An excellent reagent for the derivatization of compounds in analysis to increase their volatility, especially for volatile TMS derivatives.1 Used extensively for derivatizing alcohols, amines, carboxylic acids, phenols, steroids, biogenic amines and alkaloids.1,2 It is not recommended for use with carbohydrates or low molecular-weight compounds. BSA-DMF is the most suitable reagent for derivatizing phenols. a good source of the trimethylsilyl group in protecting functional groups. 3,4
1. J. Am. Chem. Soc. 1966, 88, 3390.
2. J. Chromatogr. A 2005,1095, 201.
3. Nucleosides Nucleotides Nucleic Acids 2000,19, 1093.
4. J. Chromatogr. A 2006,1108, 121.