Widely used for protection of amino groups in peptide synthesis and multi-step organic synthesis of small molecules.1,2,3,4 This carbamate protecting group is not hydrolyzed under basic conditions and is inert to many other nucleophilic reagents.5
1. J. Org. Chem. 2001, 66, 4261.
2. ‘Fluorous Protecting groups and Tags’ in Handbook of Fluorous Chemistry, 2004, 222.
3. Synthesis 2002, 15, 2195.
4. Mol. Pharm. 2005, 2, 273.
5. Protecting groups Edition 3, 2005, 510.