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001496

001496-250mg



Ethyl 2-chloro-3-keto-4,4,4-trifluorobutyrate


CAS Number: 363-58-6
   
Molecular Formula: C6H6ClF3O3
   
Molecular Weight: 218.56
   
MDL Number: MFCD00041540


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001496-250mg
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001496-1g
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Purity:90%
Bp:67-71°/35mm
Density:1.39
Refractive Index:1.39
 
Pictograms:
Signal Word:Warning
Hazard Statements:H314, H318
Precautionary Statements:P280, P301 + P330 + P331, P302 + P352, P304 + P340, P305 + P351 + P338, P310
UN#:UN1760
Packing Group:III
Hazard Class:8
Flash Point:67°
Risk Statements:10-36/37/38
Safety Statements:9-23-16-33-24/25-26-28-36/37/39-38-45-63-60
SDS: See MSDS
 
Limited Quantities:5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities:Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

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A reagent for organic synthesis. Applied in reaction with dimethyl isocyanatophosphite to give oxazaphospholine,1 synthesis of a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists [(6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-yl)- methyl]amines,2 synthesis of 2-aminoethyl-5-carbethoxythiazoles,3 synthesis of novel 2-methyl-4-trifluoromethyl-thiazole-5-carboxamide derivatives,4 and synthesis of new trifluoromethylated 1,3-oxazolecarboxanilides.5

Reference

1.        Zh. Obshchei Khim. 199363, 2233.
2.        Bioorg. Medicinal Chem. Lett. 201020, 3669.
3.        Tetrahedron Lett. 200546, 2251.
4.        J. Fluorine Chem. 2004125, 1287.
5.        Agric. Chem. Biotechnol. 200245, 37.

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