A homobifunctional reagent mainly used in biotechnology. For example, DVS is useful in obtaining the conjugate of BSA with the releasing factor of luteinizing hormone for immunological application;1 the ability of DVS to cross link polypeptide chains was used to prepare dimmers of the bovine and human liver ribonuclease;2 DVS was also used in affinity chromatography to activate agarose for subsequent attachment of ligands.3 The other applications include: trapping of thiol-terminated acrylate polymers to generate well-defined semitelechelic Michael acceptor polymers4, as a postdigestion modifier for enhancing the a1 Ion in MS/MS and postsource decay5 and synthesis of tertiary phosphine sulfides6.
1. J. Immunol. Methods 1995, 181, 187.
2. Org. Biomol. Chem. 2010, 8, 667.
3. Russ. J. Bioorg. Chem. 2003, 29, 227.
4. Macromolecules 2009, 42, 7657.
5. Anal. Chem. 2004, 76, 3958.
6. Russ. J. Gen. Chem. 2006, 76, 1201.