A coupling reagent for solid-phase peptide synthesis without forming carcinogenic HMPA as by-product 1. Used extensively in the preparation of non-substituted amides and N-monosubstituted amides 2. An excellent activator for converting unsubstituted amides or thioamides to nitriles and for activating monothiocarboxylic acids to prepare thioamides 2.
1.Tetrahedron Lett. 2006, 47, 5893
2.Handbook of Reagents for Organic Synthesis. 1999, 32