Peptide and oligonucleotides reagents. Commonly used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis 1, synthesis of nucleoside phosphoramidites 2, synthesis of novel nucleosides 3,4, synthesis of 1-alkyl dicyanoimidazole derivatives and as a precursor to 2-bromo-4,5-dicyanoimidazole 5. It is an alternative to the tetrazole-based activators and is less acidic but is a much more nucleophilic activator.
1. Nucleic Acid Res. 1998, 26, 1046.
2. Tetrahedron Lett. 1996, 37, 973.
3. J. Am. Chem. Soc. 2009, 131, 8496
4. Nucleosides & Nucleotides 1994, 13, 2307
5. Encyclopedia of Reagents for Organic Synthesis, 2001