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024895
TOTU
CAS Number: 136849-72-4
Molecular Formula: C12H17BF4N4O4
Molecular Weight: 368.10
MDL Number: MFCD00192127
Structure of TOTU
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024895-5g
 $33.00 
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024895-25g
 $125.00 
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024895-100g
 $357.00 
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New uronium-based coupling reagent for peptide synthesis suitable for critical cases, which give high yields with minimal racemisation, simple reaction conditions and short reaction time.1,2 Applied as reactant for Watson-Crick pairing of oligonucleotides to give β-D-Xylopyranosyl-(4'→2')-oligonucleotides containing adenine and thymine as nucleobases,and esterification of nucleosides to solid phase supports.4 Also as a reagent for the synthesis of selective integrin avβ3 antagonists,5 design and synthesis of double stranded DNA libraries,6 preparation of conformationally contrained β-amino acid derivatives,7 synthesis and application of methyleneoxy pseudopeptide building blocks,8 preparation of tritiated oostatic peptides for study of radioactivity incorporation in flesh fly Neobellieria bullata.9

References

1.        Chem. Soc. Rev. 200938, 606.
2.        Proc. 21st Eur. Pept. Symp.: Peptides 1990,  1991, 143.
3.        Helv. Chim. Acta 200285, 399.
4.        Bioconjug. Chem. 199910, 1051.
5.        Bioorg. Med. Chem. Lett. 200818, 5271.
6.        Biopolymers 200684, 400-407
7.        J. Org. Chem. 200570, 9798.
8.        Amino Acids 200427, 19.
9.        Amino Acids 201133, 489.
Properties
Purity: 98%
Bp:
Mp: 145° (dec.)
Density:
Refractive Index:
Safety
RTECS:
Risk Statements:
Safety Statements:
MSDS: See MSDS