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043278
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Ethyl (Hydroxyimino)cyanoacetate
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| Product Number | Your Price | Order |
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043278-25g |
$30.00 |
In stock
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043278-100g |
$90.00 |
In stock
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043278-500g |
$225.00 |
In stock
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A coupling reagent for peptide synthesis whose coupling efficiency in solid and liquid phase peptide coupling is superior to HOBt, and at least comparable to HOAt 1. Has a remarkable capacity to inhibit racemization as an additive in carbodiimide mediated amide bond formation 2. Also used in resin-to-resin acyl- and aminoacyl-transfer reactions as oxime supports 3. Advantages of ethyl (hydroxyimino)cyanoacetate include 2: non-explosive replacement for HOBt and HOAt;outperforms HOAt in sterically demanding peptide bond formation;suitable for carbodiimide mediated peptide coupling; less epimerization than HOBt in fragment condensation reactions. 1. Chem.–Eur. J. 2009, 15, 9394 2. Chem.–Eur. J. 2009, 15, 9404 3. J. Am. Chem. Soc.1999, 121, 1636 |
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