Also known as triflic acid, TFMS, TFSA, HOTf or TfOH. Mainly used in research as a catalyst for esterification.1 Also applied in the following reactions: Friedel-Crafts alkylation and acylation, polymerization of olefins, polymerization of ethers and siloxanes, Diels-Alder reactions, hydrogenation of alkenes, deblocking reactions, and cyclizations.2,3,4,5 A deglycosylation agrent that has been used extensively to remove carbohydrate from glycoproteins, while leaving the protein backbone intact.6
1. Chemical Reviews 1977, 77, 69.
2. Chim. Oggi. 2004, 48.
3. J. Appl. Polym. Sci. 2006, 101, 3666.
4. Tetrahedron, 2002, 58, 8475.
5. J. Am. Chem. Soc. 2002, 124, 3808.
6. Biochem. J. 2003, 376, 339.