Abbreviated as DMF·DMA. An alkylating agent used in the synthesis of esters from acids, ethers from phenols, and thioethers from aromatic and heterocyclic thiols.1,2 Used as a formylating agent in the synthesis of enaminones from active methylene compounds and amidines from amines and amides.1,2 Applied in a variant of the Claisen ortho-ester rearrangement,3 synthesis of polyfunctionally substituted pyridine derivatives as precursors to bicycles and polycycles,4 catalyzing cycloaddition of vinylarenes with electron-deficient alkynes to afford 1,2-disubstituted-3,4-dihydronaphthalenes,5 catalyzing formation of 1,3,5-trisubstituted benzene derivatives from a,b-unsaturated nitro compounds,6 N3-alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides,7 synthesis of ethyl 1,4-dihydro-4-oxo-3-quinolinecarboxylates by a tandem addition-elimination-SNAr reaction,8 reaction with benzeneacetic acid Et ester or 4-nitrobenzeneacetic acid Et ester in the synthesis of nicotinonitrile and diazepine derivatives under microwave irradiation,9 and microwave-assisted methylation of phenols.10
Reference
1. Tetrahedron 1979, 35, 1675.
2. Synlett 2002, 1741.
3. Org. Lett. 2006, 8, 4247.
4. J. Heterocycl. Chem. 2007, 44, 787–791.
5. Org. Biomol. Chem. 2007, 5, 1854
6. Bull. Korean Chem. Soc. 1999, 20, 1255.
7. Org. Biomol. Chem. 2011, 9, 6089.
8. J. Heterocycl. Chem. 2011, 48, 620.
9. J. Saudi Chem. Soc. 2011, 15, 155.
10. Tetrahedron Lett. 2011, 52, 2776.