A Reagent to introduce the tert-butyldiphenylsilyl (TBDPS) group that is an exceedingly sterically hindered hydroxyl protecting group, especially in the protection of alcohols.1 The t–butyldiphenylsilyl protecting group is considerably more stable (approximately 100 times) than the t–butyldimethylsilyl protecting group toward acidic hydrolysis.1 Applied in a variety of complex natural product syntheses.2,3,4
1. Protective Groups in Organic Synthesis, 3rd Edition 1999, 141
2. Resonance 2002, 7(12), 48.
3. J. Phys. Chem. B 2004, 108, 12640.
4. Chin. Chem. Lett. 2000, 11, 883.